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Accutane is derived from Vitamin A, which has been used to fight acne since Different companies have developed numerous Vitamin-A based acne treatments over the years, including retin-A, isotretinoin and Accutane. Before the release of Accutane, severe acne was primarily treated with oral antibiotics like tetracyclines and erythromycin. While these drugs worked for some patients, they were only effective against one of the bacteria that cause acne, Propionibacterium. Over time, these antibiotics grew less and less effective as the bacteria developed more resistant strains. Another early method of treating acne was to use high doses of fat soluble vitamin A.

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