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The use of generic drugs has become increasingly common in clinical practice. However, for drugs with a narrow therapeutic index, such as warfarin, there may be some concern regarding the definition of bioequivalence. Eleven studies, with a total of more than 40, patients, were included; five were randomized controlled trials, and six were observational studies.

   
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The clinical translation of these PK variations may be more pronounced in the elderly. Clinical monitoring and dose adjustment may thus be required. Upon co-administration of known inducers of the CYP3A4, the plasma concentration of amlodipine may vary.

   
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