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In adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with Vitamin K antagonists VKA and who have a low bleeding risk, clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke. Since higher doses of ASA were associated with higher bleeding risk it is recommended that the dose of ASA should not be higher than mg. Combined therapy should be started as early as possible after symptoms start and continued for at least four weeks. The benefit of the combination of clopidogrel with ASA beyond four https://rxsaver.retailmenot.com weeks has not been studied in this setting see section 5. In patients with atrial fibrillation, clopidogrel should be given as a single daily dose of 75 mg.

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Common side effects include headache, nausea, easy bruising, itching, and heartburn. Clopidogrel was patented in, and approved for medical use in It is also used, along with acetylsalicylic acid ASA, aspirin, for the prevention of thrombosis after placement of a coronary stent or as an alternative antiplatelet drug for people intolerant to aspirin. In people with healed ASA-induced ulcers, however, those receiving ASA plus the proton-pump inhibitor PPI esomeprazole had a lower incidence of recurrent ulcer bleeding than those receiving clopidogrel. Serious adverse drug reactions associated with clopidogrel therapy include.

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