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Zofran ondansetron is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Common side effects of Zofran include: diarrhea, headache, fever, lightheadedness, dizziness, weakness, tiredness, drowsiness, constipation, rash, blurred vision, and muscle spasm. Zofran adult dose is mg given as a single dose or divided in three 0. Zofran may interact with arsenic trioxide, tacrolimus, antibiotics, antidepressants, anti- malaria medications, heart rhythm medicines, medicine to prevent or treat nausea and vomiting, medicines to treat psychiatric disorders, migraine headache medicines, narcotics, or seizure medications. Tell your doctor all medications and supplements you use.

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