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Evaluate hematologic status before and during treatment weekly for cancer and every 2 weeks for sickle cell disease. Do not initiate therapy if bone marrow function is markedly depressed. Advise patients to report any signs and symptoms of infection e. Recovery from myelosuppression is usually observed within 15 days of therapy interruption; resume therapy at a lower dose. Some patients, treated at the recommended initial dose for sickle cell anemia, have experienced severe or life-threatening myelosuppression.

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  • Hydroxyurea is a gel to off-white crystalline powder.
  • Because of the potential for serious adverse reactions in a breastfed child from hydroxyurea, pregnancy was interrupted voluntarily or upon medical advice, there was no evidence of an effect of azithromycin mg daily for 3 days on the AUC and C max of sildenafil or its major circulating metabolite.
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Since these changes may be asymptomatic, ophthalmologic examination at periodic intervals is desirable in patients receiving prolonged therapy. Patients experiencing eye complaints or visual disturbance should have an ophthalmologic examination.


Herbert (taken for 1 to 7 years) 07.09.2018

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The linearity test was done by spiking drug-free plasma with known amounts of the drug to achieve the concentrations of 0. Intra-day reproducibility was determined by analyzing 5 aliquots of spiked human plasma and inter-day reproducibility was determined over 3 consecutive days. These samples were used to investigate the stability of indinavir over a period of 1 week.


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