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Risk for cardiovascular events seems to be higher in the early morning, also as consequence of a rise in blood pressure BP values due to the characteristic circadian pattern of BP variability. Therefore, a suitable therapeutic BP control should be tightest during the early morning. On the basis of the ambulatory blood pressure monitoring ABPM studies, it has been previously demonstrated that the antihypertensive effect of once daily drug, generally administrated in the morning, decreases at the end of the dosing period. A chronotherapeutic approach to the management of hypertension this field has been pourly investigated so far would allow the assessment of the optimum timing of drug dosing, according to the circadian BP rhythm and to the chronorisk maps, in hypertensive patients affected by associated vascular pathologies. This would increase the therapeutic effects. Patients were randomised to take the drug at 8. Lisinopril administration at Frequently asked questions. Didn't get the message? Find out why

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