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Your doctor will probably start you on a low dose of topiramate and gradually increase your dose, not more than once every week. Topiramate may control your seizures or migraines but will not cure your condition. Continue to take topiramate https://www.lodivet.com even if you feel well. Do not stop taking topiramate without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking topiramate, you may have severe seizures, even if you have not had seizures in the past.

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In patients older than 2 years of age, clinical experience in epilepsy indicates that the frequency of fatal hepatotoxicity decreases considerably in progressively older patient groups. An increased risk of valproic acid-induced acute liver failure and resultant deaths have been observed in patients with hereditary neurometabolic syndromes caused by mutations in the mitochondrial DNA polymerase gamma POLG gene e. Most of the cases were reported in children and adolescents. Severe or fatal hepatotoxicity induced by valproic acid may be preceded by nonspecific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, and vomiting. In epileptic patients, loss of seizure control also may precede the development of hepatotoxicity.

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Roland (taken for 1 to 5 years) 18.04.2019

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